3-Phenylpropanoylfentanyl (β'-phenylfentanyl) is an
opioidanalgesic that is an
analog of
fentanyl, which was invented in 1981,[2] and has been sold as a
designer drug, first identified in March 2017 in Sweden.[3]
Side effects
Side effects of
fentanyl analogs are similar to those of fentanyl itself, which include
itching,
nausea and potentially serious
respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[4] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence. Since 2016 these drugs have been responsible for hundreds of overdose deaths every week.[5]
Legal status
3-Phenylpropanoylfentanyl was banned in Finland in September 2017,[6] and in Sweden in October 2017.[7] It was also banned in Lithuania in 2017.[8] Banned in United States on April 27, 2021 (schedule 1 of the Controlled Substances Act).[9]
^Drug Enforcement Administration, Department of Justice (2018). "Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order". Federal Register. 83 (25): 5188–92.
PMID29932611.
^Zhu YQ, Ge GL, Fang SN, Zhu YC, Dai QY, Tan ZY, Huang ZM, Chen XJ (March 1981). "[Studies on potent analgesics. I. Synthesis and analgesic activity of derivatives of fentanyl (author's transl)]". Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 16 (3): 199–210.
PMID6264735.