The 1952 United States Senate election in Wyoming took place November 4, 1952. Incumbent Democratic senator
Joseph C. O'Mahoney ran for his fourth consecutive term. He faced a strong challenge from Republican governor
Frank A. Barrett, and faced difficult headwinds as
Dwight D. Eisenhower, the Republican nominee for president, was winning Wyoming
in a landslide over Democratic nominee
Adlai Stevenson. Despite his history of strong performances in the increasingly conservative state, however, O'Mahoney was unable to replicate it, and narrowly lost to Barrett. However, O'Mahoney would return to the Senate less than two years later; following the death of Senator
Lester C. Hunt, he was elected to the Senate once again in the
1954 election.