The 1926 United States Senate election in Missouri took place on November 2, 1926 in
Missouri. The
Republican Senator elected in
1920,
Selden P. Spencer, died on May 16, 1925.
George Howard Williams was appointed to continue Spencer's term on May 25, and ran for a full term in this election. He was defeated by the
Democratic nominee
Harry B. Hawes, who won 51% of the vote. Hawes also defeated Williams in the
special election held the same day.