In enzymology, a (R)-limonene 6-monooxygenase ( EC 1.14.13.80) is an enzyme that catalyzes the chemical reaction

(+)-(R)-limonene + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ (+)-trans-carveol + NADP⁺ + H₂O

The 4 substrates of this enzyme are (+)-(R)-limonene, NADPH, H⁺, and O₂, whereas its 3 products are (+)-trans-carveol, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include (+)-limonene-6-hydroxylase, and (+)-limonene 6-monooxygenase. This enzyme participates in monoterpenoid biosynthesis and limonene and pinene degradation.

See also

• CYP2C19

References

• Bouwmeester HJ, Gershenzon J, Konings MC, Croteau R (1998). "Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration Of enzyme activities and their changes with development". Plant Physiol. 117 (3): 901–12. doi: 10.1104/pp.117.3.901. PMC  34944. PMID  9662532.
• Croteau R (1999). "Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum Carvi)". Phytochemistry. 50 (2): 243–248. doi: 10.1016/S0031-9422(98)00516-0.