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Computational biology professor
Sohini Ramachandran is professor at
Brown University known for her work in
evolutionary biology and
population genetics .
Early life and education
Ramachandran's parents were both professors.
[1] In the summer before her senior year of high school, Ramachandran completed a research project in plant genomics under the guidance of
Marcus Feldman , which won her the fourth place prize in the 1998 Westinghouse Science Talent Search,
[2] where when she was the youngest finalist in the group.
[3] Ramachandran earned a B.S. from
Stanford University in 2002. She went on to complete a Ph.D. at
Stanford University in the Department of Biological Sciences, advised by
Marcus Feldman . Her dissertation research was dissertation was titled "The signature of historical migrations on human population genetic data."
[4] Following her PhD, she was in the
Harvard Society of Fellows as a postdoctoral researcher with John Wakeley in
Harvard University 's Department of Organismic and Evolutionary Biology.
[5] She moved to Brown University in 2010 and was promoted to professor in 2021.
[5] In 2019, she was a fellow at the
Swedish Collegium for Advanced Study .
[6]
Research
Ramachandran's research group uses statistical and mathematical modeling techniques to study
evolutionary biology and
population genetics . Her early research examined the genetic relationships originating within people from Africa,
[7]
[8] where she showed that diversity decreases as distance from Africa increases.
[9] She has also investigated the use of genetic tools to track infectious diseases
[10]
[11] and shown that while more outbreaks are occurring, fewer people are getting infected.
[12] She has also shown a lack of genetic evidence for selection for language at the
FOXP2 site.
[13]
Selected publications
Li, Jun Z.; Absher, Devin M.; Tang, Hua; Southwick, Audrey M.; Casto, Amanda M.; Ramachandran, Sohini; Cann, Howard M.; Barsh, Gregory S.; Feldman, Marcus; Cavalli-Sforza, Luigi L.; Myers, Richard M. (2008-02-22).
"Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation" . Science . 319 (5866): 1100–1104.
Bibcode :
2008Sci...319.1100L .
doi :
10.1126/science.1153717 .
ISSN
0036-8075 .
PMID
18292342 .
S2CID
53541133 .
Ramachandran, Sohini; Deshpande, Omkar; Roseman, Charles C.; Rosenberg, Noah A.; Feldman, Marcus W.; Cavalli-Sforza, L. Luca (2005).
"Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa" . Proceedings of the National Academy of Sciences . 102 (44): 15942–15947.
Bibcode :
2005PNAS..10215942R .
doi :
10.1073/pnas.0507611102 .
ISSN
0027-8424 .
PMC
1276087 .
PMID
16243969 .
Wang, Sijia; Lewis, Cecil M. Jr.; Jakobsson, Mattias; Ramachandran, Sohini; Ray, Nicolas; Bedoya, Gabriel; Rojas, Winston; Parra, Maria V.; Molina, Julio A.; Gallo, Carla; Mazzotti, Guido (2007-11-23).
"Genetic Variation and Population Structure in Native Americans" . PLOS Genetics . 3 (11): e185.
doi :
10.1371/journal.pgen.0030185 .
ISSN
1553-7404 .
PMC
2082466 .
PMID
18039031 .
Ramachandran, Sohini; Rosenberg, Noah A.; Zhivotovsky, Lev A.; Feldman, Marcus W. (2004).
"Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites" . Human Genomics . 1 (2): 87–97.
doi :
10.1186/1479-7364-1-2-87 .
ISSN
1479-7364 .
PMC
3525066 .
PMID
15601537 .
Honors and awards
In 2012, Ramachandran received a
Sloan Research Fellowship
[14] and was named a Pew Scholar.
[15] From Brown University she has received the Henry Merritt Wriston Fellowship (2016)
[16] and the Philip J. Bray Award for excellence in teaching.
[17] In 2019, she received a
Presidential Early Career Award in Science and Engineering .
[18]
[19]
References
^ Chen, Ling-Ling; Claw, Katrina G.; Ramachandran, Sohini (2016).
"A two-fold challenge: the experience of women of color in genomics" . Genome Biology . 17 (1): 210.
doi :
10.1186/s13059-016-1075-0 .
ISSN
1474-760X .
PMC
5059990 .
PMID
27729075 .
^ Chiu, Yvonne (1998-03-09).
"Fair Oaks teen gets national honor" . The Sacramento Bee . p. 2. Retrieved 2022-04-17 .
^ Alcala, Carlos (1998-01-28).
"Fair Oaks teen, like sister, is on academic fast track" . The Sacramento Bee . pp.
[1] ,
[2] . Retrieved 2022-04-17 .
^ Ramachandran, Sohini (2007).
The signature of historical migrations on human population genetic data (Thesis).
OCLC
269371999 .
^
a
b
"Sohini Ramachandran Lab: people" . brown.edu . Retrieved 2022-04-17 .
^
"SCAS: Sohini Ramachandran" . www.swedishcollegium.se . Retrieved 2022-01-22 .
^ Ramachandran, Sohini; Deshpande, Omkar; Roseman, Charles C.; Rosenberg, Noah A.; Feldman, Marcus W.; Cavalli-Sforza, L. Luca (2005).
"Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa" . Proceedings of the National Academy of Sciences . 102 (44): 15942–15947.
Bibcode :
2005PNAS..10215942R .
doi :
10.1073/pnas.0507611102 .
ISSN
0027-8424 .
PMC
1276087 .
PMID
16243969 .
^ Henn, Brenna M.; Gignoux, Christopher R.; Jobin, Matthew; Granka, Julie M.; Macpherson, J. M.; Kidd, Jeffrey M.; Rodríguez-Botigué, Laura; Ramachandran, Sohini; Hon, Lawrence; Brisbin, Abra; Lin, Alice A. (2011-03-29).
"Hunter-gatherer genomic diversity suggests a southern African origin for modern humans" . Proceedings of the National Academy of Sciences . 108 (13): 5154–5162.
doi :
10.1073/pnas.1017511108 .
ISSN
0027-8424 .
PMC
3069156 .
PMID
21383195 .
^ Scudellari, Megan (June 2012).
"Sohini Ramachandran: Population Tracker" . The Scientist Magazine® . Retrieved 2022-04-17 .
^ Smith, Katherine F.; Goldberg, Michael; Rosenthal, Samantha; Carlson, Lynn; Chen, Jane; Chen, Cici; Ramachandran, Sohini (2014-12-06).
"Global rise in human infectious disease outbreaks" . Journal of the Royal Society Interface . 11 (101): 20140950.
doi :
10.1098/rsif.2014.0950 .
PMC
4223919 .
PMID
25401184 .
^ Nakka, Priyanka; Raphael, Benjamin J; Ramachandran, Sohini (2016-10-01).
"Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases" . Genetics . 204 (2): 783–798.
doi :
10.1534/genetics.116.188391 .
ISSN
1943-2631 .
PMC
5068862 .
PMID
27489002 .
^ Berman, Jessica (October 29, 2014). "Global Infection Outbreaks Rise over Past 30 Years". Voice of America News / FIND; Washington .
^ Atkinson, Elizabeth Grace; Audesse, Amanda Jane; Palacios, Julia Adela; Bobo, Dean Michael; Webb, Ashley Elizabeth; Ramachandran, Sohini; Henn, Brenna Mariah (2018-09-06).
"No Evidence for Recent Selection at FOXP2 among Diverse Human Populations" . Cell . 174 (6): 1424–1435.e15.
doi :
10.1016/j.cell.2018.06.048 .
ISSN
0092-8674 .
PMC
6128738 .
PMID
30078708 .
^
"Sohini Ramachandran, Ph.D." pew.org . August 23, 2012. Retrieved 2022-01-13 .
^ "Eight Women Win Pew Scholarships in the Biomedical Sciences". Women in Academia Report; Bartonsville . July 3, 2012.
^
"Sohini Ramchandran awarded Wriston Fellowship" . CCMB | Brown University . Retrieved 2022-04-17 .
^ Gimenes, Livia (2021-07-03).
"Sohini Ramachandran Receives The Philip J. Bray Award For Excellence In Teaching In The Physical Sciences" . awards.cs.brown.edu . Retrieved 2022-04-17 .
^
"Two Brown researchers earn top White House award for early-career scientists" . Brown University . Retrieved 2022-01-13 .
^ Abbey Bigler and Talylor Walter (26 February 2020).
"PECASE Honoree Sohini Ramachandran Studies the Genetic Foundations of Traits in Diverse Populations" . NIGMS Biomedical Beat Blog . Retrieved 2022-04-17 .
External links
External links